HER2-positive breast cancer is an aggressive form of breast cancer that tests positive for the human epidermal growth factor receptor 2 (HER2) protein. This type of breast cancer tends to grow and spread more quickly than HER2-negative cancers. Fortunately, breakthrough treatments such as Kisqali Pi and targeted therapies are transforming care and improving outcomes for patients.
Breakthrough Treatments for HER2 Metastatic Breast Cancer
Over the past two decades, targeted therapies have revolutionized how doctors treat HER2-positive breast cancer. Key treatments include:
- Trastuzumab (Herceptin): One of the first targeted therapies, trastuzumab works by binding to HER2 proteins, slowing tumor growth and enhancing survival rates.
- Pertuzumab (Perjeta): Often used in combination with trastuzumab, pertuzumab provides even greater benefits for patients with advanced HER2-positive breast cancer.
- Kisqali Pi: While primarily used for hormone receptor-positive breast cancer, ongoing research is exploring its potential in combination with other therapies for HER2-positive cases.
- Antibody-drug conjugates (ADCs): These drugs, such as ado-trastuzumab emtansine (Kadcyla), deliver chemotherapy directly to cancer cells with HER2 overexpression.
Managing Side Effects of HER2 Treatments
While targeted therapies have improved outcomes, they can also cause side effects, such as:
- Fatigue
- Nausea and vomiting
- Diarrhea
- Heart problems (cardiotoxicity)
- Skin rash
Your healthcare team may recommend medications to ease symptoms, as well as lifestyle changes like balanced nutrition, gentle exercise, and stress management techniques.
The Role of Immunotherapy in HER2 Breast Cancer
Immunotherapy represents an exciting new frontier for HER2-positive breast cancer treatment. These therapies boost the body’s immune system, helping it identify and attack cancer cells. While not yet standard care for HER2-positive breast cancer, ongoing clinical trials are investigating immunotherapy drugs, either alone or in combination with targeted therapies, to enhance treatment response.
Living with HER2 Metastatic Breast Cancer: Tips for Patients
Being diagnosed with metastatic breast cancer can feel overwhelming, but with the right support and strategies, you can maintain quality of life. Helpful tips include:
- Building a strong support network of family, friends, and fellow patients.
- Maintaining open communication with your oncology team.
- Following a healthy lifestyle with balanced nutrition, gentle exercise, and rest.
- Exploring counseling, support groups, and integrative therapies to manage emotional health.
- Staying informed about new treatments and clinical trial opportunities.
With continued research and the development of innovative therapies, the outlook for HER2-positive breast cancer continues to improve, offering hope to patients and their loved ones.